I'm not really sure.

The thing about BotW is that its item system is much different than any other Zelda game, typically Zelda follows a linear pattern with how you obtain items which also affects how you approach dungeons and creates an order to it because you were required to use certain items to complete a dungeon but that no longer applies.

I'm guessing they all have different difficulties but so long as you have decent items and general skill in the game it's possible to do them however you please.

What we have with the Sheikah Slate (one of the main items which you get at the start) are rune abilities obtained through Shrines of Trials that can vastly change how you play the game and go about doing dungeons/fighting.

We've seen 4 runes so far:

The Cryonis Rune allows Link to create ice pillars in the water in order to make his way to otherwise inaccessible terrain.

The Magnesis Rune, which lets Link grab and lift metal objects from afar, such as a chest sitting at the bottom of a lake.

The Round Bomb, a round bomb that can be summoned repeatedly (after a short cooldown).

The Statis Rune, which gives Link the ability to lock objects in place and manipulate them.

This is such a different experience we'll just have to wait and see.

Part of the story is not only defeating Ganon but because there is a 100 year gap before Link is awakened we gradually learn what everything is and why it's become the way it is.